FEBS Lett. MacArthur, M. Ramachandran, G. Schubert, M. Stewart, D. Weiss, M. Biopolymers 50 — Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account.
Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Doreen Pahlke , Doreen Pahlke. Oxford Academic. Google Scholar. Dietmar Leitner. Urs Wiedemann. Dirk Labudde. Revision received:. Select Format Select format. Permissions Icon Permissions. Abstract Summary: COPS predicts for all 20 naturally occurring amino acids whether the peptide bond in a protein is in cis or trans conformation.
Open in new tab Download slide. Issue Section:. Download all slides. View Metrics. Email alerts Article activity alert. Advance article alerts. New issue alert. Receive exclusive offers and updates from Oxford Academic. Related articles in Web of Science Google Scholar. Citing articles via Web of Science Latest Most Read Most Cited Deep graph representations embed network information for robust disease marker identification.
T2-DAG: a powerful test for differentially expressed gene pathways via graph-informed structural equation modeling. Deep graph learning of inter-protein contacts. Looking for your next opportunity? Physician-Scientist Faculty Position. Ramachandran plots can be constructed for polymers of each of the 20 amino acids. It is significant to note that the Ramachandran plots for many amino acid residues are generally very similar, having only three regions with favourable or tolerated conformations labelled 1—3 in the plot for poly- l -alanine in Figure 5.
Differences do occur, however. Figure 6 shows the Ramachandran plot for glycine residues in a polypeptide chain. The regions are colour-coded as in Figure 5. What can you say about the conformations that glycine adopts? Consider the structure of glycine. Why does glycine differ from the other residues with respect to its conformations? Glycine has much greater conformational freedom than do other amino acid residues, because it is less sterically hindered.
The Ramachandran plots in Figures 5 and 6 have been generated for, respectively, l -alanine and l -glycine on the basis of allowed and outer limit distances for interatomic contacts, determined from known values for van der Waals radii of the atoms Table 1. They are therefore predictive rather than actual conformational plots. We can see that there is a striking correspondence between predicted and actual conformations.
What groups are likely to conflict in this conformation? The N—H groups of adjacent peptide groups will conflict with each other, being forced into close proximity. The conflict associated with these conformations can be accommodated by a small degree of twisting of the peptide bond. Thus, in such conformations the peptide group is twisted out of its usual planar conformation. A polypeptide will tend to fold such that it adopts the most stable conformation.
In this conformation, the polypeptide minimises its free energy. In the next sections, we shall look at this higher level of protein structure. Making the decision to study can be a big step, which is why you'll want a trusted University.
Take a look at all Open University courses. If you are new to University-level study, we offer two introductory routes to our qualifications. You could either choose to start with an Access module , or a module which allows you to count your previous learning towards an Open University qualification. Read our guide on Where to take your learning next for more information. Not ready for formal University study? Then browse over free courses on OpenLearn and sign up to our newsletter to hear about new free courses as they are released.
Every year, thousands of students decide to study with The Open University. Request an Open University prospectus OpenLearn works with other organisations by providing free courses and resources that support our mission of opening up educational opportunities to more people in more places.
All rights reserved. The Open University is authorised and regulated by the Financial Conduct Authority in relation to its secondary activity of credit broking. Skip to main content. Search for free courses, interactives, videos and more! Free learning from The Open University. Featured content. Free courses. All content. Course content. About this free course 12 hours study. Level 3: Advanced. Course rewards. Free statement of participation on completion of these courses. Create your free OpenLearn profile.
Course content Course content.
0コメント